crohns and heredity

by jennie
(canada)

hi would my daughter have crohns disease even though i don't have it but her father does

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crohns and heredity NEW
by: Annette Young

Hello there,

Sadly your daughter does have a greater chance of developing Crohn's disease even though just one of her parents has the condition.

There is certainly an enhanced risk when parents or family members have Crohn's disease. Experts certainly feel that one or more genes make people more susceptible to this disease.

You don't say how old your daughter is but I would certainly keep an eye on her symptoms if they start to materialise, these can vary of course often include abdominal cramping, pains, diarrhoea, blood in the stools and nausea but symptoms do vary from person to person.

Not everyone gets the full force of Crohn's disease, some people get more mild symptoms and others unfortunately can feel quite poorly with it. Ideally, if you can get your daughter onto a healthy and simplistic diet now, it may help to keep her digestive tract balanced, she can also learn basic relaxation techniques which will enable her to deal with stress as they arise. I say this because stress is a well-known trigger for Crohn's and although it is not the cause it can certainly make it worse.

Here is some information that might be useful:
http://www.mayoclinic.com/health/crohns-disease/DS00104/DSECTION=causes
http://www.webmd.com/ibd-crohns-disease/crohns-disease/digestive-diseases-crohns-disease

The most important thing is to not worry about it at this stage. Just stay sharp and if you think that she might be developing symptoms then seek out professional help.

If anyone else has information on crohn’s and family links do get in touch with us.
Best wishes,
Annette
crohns and heredity NEW
by: Lydia D.

Yes, you are most likely are a carrier of some of the 71 identified gene loci, which increase the risk of Crohn's disease.

Researchers estimate that there could be well over 300 different genome risk loci involved in determing the various Crohn's subtypes.

http://www.nature.com/nature/journal/v474/n7351/full/nature10209.html

http://www.genomeweb.com/sequencing/sequencing-gwas-loci-uncovers-rare-variants-independently-contribute-crohns-dise

If you have another (autoimmune) disease, for example: ulcerative colitis, coeliac disease, psoriasis, diabetes, lupus erythrematosus, rheumatoid arthritis, etc., this can also increase the risk of offspring developing Crohn's disease because of overlapping genome risk loci between diseases.

http://en.wikipedia.org/wiki/Crohn%27s_disease



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